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Although NTIS is associated with significantly worse prognosis, it is also assumed to represent a beneficial adaptation (type 1 allostasis)

The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages

Blood 90:71a, 1997

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Unexpectedly, female mice, regardless of genotype, had no significant changes in whole body metabolism when comparing light and dark phases