We confirmed that GCLC-KO mice have significantly reduced GCLC and glutathione levels, and an elevated ratio of oxidized to total glutathione in their brains (Fig
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This doesn't mean you have to pick a favorite and ditch the rest
Although the majority of readouts are at bulk level, mitochondrial changes in mass and morphology at single-cell resolution suggest an adaptive response rather than a selection for pre-existing tolerant cells in clonal lines
Recent studies indicate a correlation between ferroptosis and the emergence of female reproductive disorders, such as polycystic ovary syndrome, premature ovarian insufficiency, endometriosis, ovarian cancer, preeclampsia, and spontaneous abortion
Science 360(6384):3637