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Fast forward 20+ years, and we now have remarkably effective and safe GLP-1s for patients with obesity, and for patients with overweight + one weight-related comorbidity

This hormone plays a key role in regulating appetite and metabolism

Even if a successful vaccine becomes available, it will be many years before entire populations can be immunized

At the same time, a natural decrease in muscle mass lowers the resting metabolism, meaning the body requires fewer calories to maintain itself than it did in previous decades

The signs of hypoglycemia may be reduced or absent in patients taking anti-adrenergic drugs (eg, betablockers, clonidine, guanethidine, and reserpine)