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In summary, these findings demonstrate that GPR146 regulates adipose function in a stage-specific manner-promoting adipogenesis via Gq-PKC-AKT signaling during differentiation and stimulating lipolysis via ERK signaling in mature adipocytes-highlighting the context-dependent nature of GPR146-mediated metabolic control

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Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: an in vitro and in vivo study in diabetic nephropathy mice model