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Extracellular mtDNA can act as a damage-associated molecular pattern (DAMP), triggering the activation of innate immune receptors such as toll-like receptors (TLRs) and inducing the production of type I interferons (IFNs) [131]
Weeks 6-8 Cycle off and reassess
Despite decades of research and a growing repertoire of molecular targets and candidate therapeutics, the field of neuroprotection remains hindered by persistent conceptual ambiguity
Dosing at 0.25-0.5 mg daily for 6-8 weeks addresses both the acute inflammation and underlying tissue damage
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