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Circulating levels peak in early adulthood and decline significantly with age dropping from roughly 200 ng/mL at age 20 to approximately 80 ng/mL by age 60

Researchers are drawn to MT-II because of how broadly it interacts with the melanocortin receptor system it's been studied across pigmentation pathways, central nervous system signalling, and neuroendocrine models

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Switching to coffee with meals, adding plant-based milk or a small amount of protein, or reducing caffeine intake often resolves the issue within days