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Store lyophilized peptides at -20C in original sealed vials to prevent degradation

During clinical trials for adjunctive treatment of Lennox-Gastaut syndrome or refractory partial onset seizures in pediatric patients 2 to 16 years of age, persistent decreases in serum bicarbonate occurred in 67% of topiramate-treated patients and 10% of placebo-treated patients

This kind of self-promotional case series does not prove either efficacy or safety if anything, it underscores the need for independent research

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Acknowledgements We thank the team of OpenGWAS and UK Biobank database for making the summary data publicly available, and we would like to acknowledge the principal investigators of the studies who made their data openly accessible for research