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Metabolic effects: GLP-1 improves insulin sensitivity and glucose metabolism, independent of weight loss
Katsiki N, Athyros VG, Karagiannis A, Mikhailidis DP
The one head-to-head trial, SURMOUNT-5, compared tirzepatide against the semaglutide injection and found tirzepatide produced greater weight loss (20.2% versus 13.7% over 72 weeks)
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Since tirzepatide has a long half-life of approximately five days, a single-day shift will not create dangerous medication levels
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