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2023;133(5):e162315

Both 25-hydroxylases (CYP2R1 and CYP27A1) were expressed in the liver, while CYP27A1 expression was seen only in cultured hepatocytes (FL83B mouse hepatocyte cell line)

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Clinical-grade products should not claim mitochondrial replacement unless a mechanism-linked potency assay demonstrates a functional mitochondrial phenotype