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SURMOUNT-1: Tirzepatide 15 mg, the generational leap of 2022 SURMOUNT-1 (Jastreboff et al., NEJM 2022, PMID 35658024) randomized 2,539 obese adults without diabetes to tirzepatide 5, 10, or 15 mg/week or placebo over 72 weeks
This includes those with a history of medullary thyroid carcinoma or thyroid tumors identified through screening
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A clinical trial has shown that ranirestat affects motor nerve function in mild to moderate DPN
For in vivo studies, drugs were aliquoted by a lead scientist in number-coded vials and most, but not all, handling investigators were blinded to the treatment condition
Lancet 2021;398:14355.ArticlePubMed 90
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