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And there can be very real negative side effectsnausea, fatigue, dizziness, muscle and hair lossand some people have even reported increased depression and suicidal ideation, although a large-scale meta study seemed to show no direct link to the medication itself

The standard weight-loss titration schedule (STEP protocol) This is the schedule used in the STEP clinical trial program, which enrolled 4,567 patients across five trials and established semaglutide as the most effective GLP-1 medication for weight loss

(2008, November)