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Participants were recruited via newspaper and radio advertisements, and by word of mouth
In conclusion, the liver selectivity of resmetirom is achieved through two complementary design principles: (i) a 28-fold higher binding affinity for THR- compared to THR- [18], and (ii) preferential first-pass hepatic extraction that results in a favorable liver-to-plasma exposure ratio
Tirzepatide, when combined with a healthy diet and physical activity, can result in considerable weight loss, up to 20%
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