Colony-stimulating factor 1 receptor (CSF1R) inhibition, which leads to microglial depletion, has shown potential to modify disease progression in multiple neurodegenerative models
By improving insulin function, GLP-1 medications can help: Reduce insulin resistance Support sustainable weight loss Improve metabolic health Stabilize blood sugar Lower androgen excess For many women with PCOS, addressing insulin resistance is one of the most effective ways to improve hormone balance and long-term health
Another meta-analysis of trials that compared the safety profile of antidepressants found evidence of fewer adverse effects, and consequently, better adherence to treatment with ALCAR compared to placebo and in contrast to classical pharmaceutical agents (96)
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The GLP-1 and GIP arms meanwhile drive insulin secretion and gastric-emptying delay in different tissues and on different timescales (PMID 39515565, PMID 41785010)