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Helen Knight, director of medicines evaluation at NICE, said: Our committee recognised the potential tirzepatide has to provide an effective and good value treatment option for all those living with poorly controlled type 2 diabetes. Poorly controlled type 2 diabetes, with its associated additional health risks, is a huge challenge for those living with the condition and the NHS. This summer it was reported that patients with type 2 diabetes on semaglutide and other glucagon-like peptide-1 receptor agonists (GLP-1 RA) drugs are having to stop taking them, amidst ongoing shortages

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Constipation is more common (believed to be due to astringent action of iron) than diarrhoea (thought to reflect irritant action)

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