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Factors that increase side effect risk While AOD 9604 has a favorable safety profile, certain factors can increase the likelihood or severity of unwanted effects

In this study, we sought to explore whether and how lipofuscin contributed to liver fibrosis, and to examine if TZP could alleviate liver fibrosis by intercepting lipofuscin accumulation and neutrophil activation

Increased serum creatinine, renal impairment, worsened chronic renal failure, and acute renal failure, sometimes requiring hemodialysis and kidney transplantation have been reported

doi: 10.1016/j.ejphar.2022.175294 165 CryanJFORiordanKJCowanCSMSandhuKVBastiaanssenTFSBoehmeMet al

The most frequently reported side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which typically diminish over time as the body adjusts to treatment

This finding suggests that GLP-1 receptor agonists may have direct or indirect effects on erectile function beyond what can be explained by metabolic improvements alone