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B12 injections work quickly and typically show noticeable effects within 48 to 72 hours
Glutathione-S-transferase variants and adult glioma [PMID: 15006924] Laboratory literature summary: Glutathione-S-transferase variants and adult glioma
B12 can hurt when injected to push the plunger slowly
(February 1968)
Special-order manufacturers Medicines guidance
Alternatively (and this is the approach I take for many patients), if you are experiencing significant symptomatic improvement then you can just continue to take the B12 shots indefinitely
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