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The HGF-stimulated phosphorylation of the following downstream phosphokinases was inhibited by SU11274: p-ERK1 [T202/Y204], p-ERK1/2 [T185/Y187], p-MEK1/2 [S221/S225], p38 p-MAP kinase [T180/Y182], p-AKT1 [S473], p-RB [S672], p-adducin- [S662], and p-CREB [S133])

It was unexpected that the concentrations of MDL29,951 that had the strongest effects on cAMP inhibition (i.e., 100-300 nM MDL29,951) had modest effects on regulation of GLP-1 secretion, and the concentrations of MDL29,951 that yielded the most robust inhibition of GLP-1 secretion (i.e., 25 M MDL29,951) had no significant effect on cAMP regulation

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PT-141 / 10mg PT-141, also known as bremelanotide, is a synthetic melanocortin-receptor peptide studied for its relevance to melanocortin signaling, receptor-binding behavior, central neuropeptide pathway research, and cellular communication models

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