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The primary molecular mechanism of TB-500 involves regulation of actin dynamics through its high-affinity binding to monomeric G-actin
doi: 10.1074/jbc.M117.800482 115 BrassALHuangICBenitaYJohnSPKrishnanMNFeeleyEMet al
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4.6 Overcoming translational barriers: In Vivo stability and manufacturing hurdles Despite the immense preclinical promise of nanomedicine in osteosarcoma, several significant translational barriers must be addressed before clinical implementation (59, 68)
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