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Functional MRI data show that Sema alters activation in brain regions involved in reward and motivation, including the insula, putamen, and orbitofrontal cortex, which are associated with food cue reactivity and cravings
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However, some products may be eligible for FSA or HSA reimbursement
If retatrutide reduces major cardiovascular events (like semaglutide did in SELECT), the heart rate increase will be viewed as a pharmacologically interesting but clinically irrelevant side effect
However, it should not be used in patients with type 1 diabetes or for treatment of diabetic ketoacidosis, and should not be coadministered with other GLP-1 receptor agonists or semaglutide-containing products
To date, Phase 3 clinical trial data have also shown significant weight-loss outcomes, including up to 28.7% average body weight loss at 68 weeks in one obesity trial and 16.8% average weight loss at 40 weeks in adults with type 2 diabetes, with additional Phase 3 readouts still expected throughout 2026
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