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Pyruvate dehydrogenase kinase 4 (PDK4) expression serves as an independent prognostic marker, predicting disease recurrence regardless of established diagnostic risk factors such as Gleason grade, clinical stage, and PSA levels (Oberhuber et al., 2020)

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An alternative ROC analysis in pwRMS regarding whether PIRA occurred or not, suggested a more optimal cut-off value of 28 that could detect earlier in time those patients at risk of progression

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Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice