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Arnold, MD, Contributing Editor The views expressed in this editorial are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Uniformed Services University of the Health Sciences, Department of Defense, Department of Veterans Affairs, or the U.S
Breakdown of glutathione, oxidized glutathione and glutathione S-conjugates happens upon uptake into the vacuole but can also take place in the cytosol and apoplast 56
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What the Data Actually Show | Evidence Level | Sermorelin Alone | GHK-Cu Alone | Sermorelin + GHK-Cu | |---|---|---|---| | Phase III RCT | Yes (pediatric GHD) | No | No | | Phase II RCT (adults) | Yes (Vittone 1997) | One skin-aging trial | No | | Animal studies | Multiple | Multiple | None identified | | In vitro mechanistic | Extensive | Extensive | None identified | | Case series / observational | Limited | Limited | Anecdotal only | The FDA-approved indication for sermorelin covers pediatric GH deficiency
The thiol groups are also of great importance in substrate binding of enzymes, in metal-sulfur clusters in proteins (e.g
