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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression
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In AML, the anti-apoptotic protein BCL-2 is upregulated, enabling leukemia cells to evade apoptosis and continue their growth (75,76)
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