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Results Dosing of mGIPR-Ab or mGIPR-Ab/GLP-1 produces weight loss To investigate the role of GIPR in energy balance in the CNS, male mice that were fed a high-fat diet (HFD) were administered intracerebroventricular (ICV) injections of varying doses of a fully human anti-human GIPR antibody that cross-reacts with mouse GIPR (mGIPR-Ab)

Following a 12-week low FODMAP diet intake, the participants exhibited a significant induction in circulating GLP-1 levels (increasing modestly from about 3.3 pM to 3.6 pM), significantly reduced body weight, and significantly improved IBS and gastrointestinal symptoms

Dou, Y., et al

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Intensive Blood-Glucose Control With Sulphonylureas or Insulin Compared With Conventional Treatment and Risk of Complications in Patients With Type 2 Diabetes (UKPDS 33)