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Although critical glutathione levels will lower as we age, depletion can be accelerated by stress, illness, infection, poor diet, alcohol, cigarettes, trauma, and environmental toxins

For patients on established B12 injection therapy, monitoring is based primarily on clinical response and haematological parameters rather than routine serum B12 measurements, which may remain very high without indicating harm or overtreatment

Severe deficiency, neurological symptoms, or malabsorption

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White blood cell count (WBC), oxidative burst (ROS activity), total serum protein (TP), total immunoglobulin (TI), and PA were measured in blood and serum to evaluate the immune response