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Delivering a copper complex systemically by injection is a different pharmacological proposition from smoothing a cream onto the epidermis, with different exposure, distribution, and safety considerations, and the topical cosmetic data do not transfer automatically to that route

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They were then washed twice using F-12 with 0.1% BSA or 0.1% casein, 33 mM HEPES, and incubated for 2 h at 37 C

The micronutrient Mg 2+ also has been proposed as a treatment for NIHL, not only for its function as a potential cochlear vasodilator but for other pharmacological properties, which include modulation of NMDA glutamate receptors and the regulation of calcium influx into hair cells, preventing or reducing apoptosis (Cevette et al., 2003