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Researchers use 5-Amino-1MQ to explore NNMT inhibition and its effects on downstream molecular signaling in controlled experimental models

Xu, K., Gao, Y., Yang, L., Liu, Y

Through GPER gene knockout or activation, researchers found that GPER-deficient mice presented increased insulin resistance, whereas GPER activation improved insulin signaling and glucose metabolism

Collectively, these data confirm the functional absence of MZB in Gclc fl/fl Mb1-Cre + mice and demonstrate that Gclc is critical for FoB-mediated GC reactions and antibody-mediated immunity to infections