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Neuroprotection against oxidative stress: phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system
Psychiatry 27, 26592673
In the rat model of isoproterenol (ISO)-induced myocardial injury, OJP (100, 200, and 300 mg/kg) could further improve myocardial enzyme indexes [aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase isoenzyme-MB (CK-MB)] by reducing the elevation of ST segment and cardiac index, increasing the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) in serum and myocardium, and reducing the level of malondialdehyde (MDA) (60)
Glial cells, i.e., microglia, astrocytes, and oligodendrocytes, are essential for supporting and modulating neuronal function [117, 118]
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The increase in bioenergetic pathways was accompanied by an activation in riboflavin metabolism
