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In a clinical trial of AIDS patients were treated with 1.8 g/day of NAC for two weeks with the glutathione (GSH) status monitored in plasma and lymphocytes

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In summary, the core breakthrough in current HIF-targeted drug development lies in establishing the regulation of ROS generation (inhibiting pathological accumulation or controllably utilizing its killing effect) as the key hub for intervening in hypoxia-related diseases

Acknowledgements This work was partially supported by grants from JSPS (KAKENHI Grant Numbers JP21K08032 and 24K11270) to KS