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Our analysis demonstrated that the use of GLP-1 RAs was associated with a significantly decreased risk of all-cause mortality, MACEs, and MAKEs over a median follow-up period of 2.5 years

Panel B of Figure 5 shows that the fluctuations in methionine input cause very large fluctuations in SAM but only modest fluctuations in intracellular methionine concentration, as suggested by the early methionine loading experiments of Finkelstein and co-workers [53, 54]

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