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2011 hip-fracture trial, which prompted the study's early termination

If metformin at a maximum tolerated dose does not achieve the HbA1c target after 3 months, add a second oral agent (a sulfonylurea [SU], thiazolidinedione [TZD], dipeptidyl peptidase 4 [DPP-4] inhibitor, or sodium-glucose cotransporter-2 [SGLT2] inhibitor), a glucagon-like peptide-1 (GLP-1) receptor agonist, or a basal insulin ( TABLE 2 )

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Rabih Wassel Chief Medical Officer MBBS, BSc, MSc, MRCS, MRCGP Dr

We are currently amid an evolving revolution in obesity pharmacotherapy, with increasingly efficacious anti-obesity medicines (AOMs), incorporating uni-, bi- and trimolecular incretin receptor agonists [8, 9]