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The availability of a peptide through a licensed pharmacy does not necessarily mean that the peptide or its intended use is FDA-approved, nor does it establish safety or effectiveness for every patient or medical condition

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With doses of 10 nmol/kg and higher, rats exhibited not only a lack of activity, but also notable changes in facial expressions associated with pain and nausea including orbital tightening and nose/cheek flattening compared to rats treated with vehicle alone

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However, these pro-apoptotic effects have thus far been demonstrated predominantly in preclinical systems and should not be directly extrapolated to clinical antitumor efficacy or systemic toxicity (78,145)