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In: editors Osborn S, Morley W
Sustainable weight loss requires long-term lifestyle changes
10.1038/nature17040 162 ReidW
Retatrutide's triple-agonist mechanism produced the highest weight loss of any anti-obesity agent in clinical trials (28.7% at 68 weeks in Phase 3 TRIUMPH-4), confirming that the addition of GIP receptor agonism to the GLP-1/glucagon backbone provides substantial incremental benefit
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