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For example, Incidence of MTHFR 677T mutations are between 10 and 36% of the population [56]

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Key ways it appears to mimic or amplify natural gastrointestinal and tissue repair mechanisms observed in animal studies: Strongly upregulates angiogenesis through multiple pathways (VEGF, EGR-1, FAK-paxillin) in injured tissues, similar to the bodys own response during normal wound healing and tendon/ligament repair

Still far below IV, but clinically relevant