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The pain can be so severe that patients avoid bowel movements and become constipated (proctogenic constipation), which worsens the situation

Ng, M., Emmanuela Gakidou, Lo, J., Abate, Y.H., Cristiana Abbafati, Abbas, N., Mohammadreza Abbasian, Samar Abd ElHafeez, Abdel-Rahman, W.M., Sherief Abd-Elsalam, Abdollahi, A., Meriem Abdoun, Abdulah, D.M., Rizwan Suliankatchi Abdulkader, Abdullahi, A., Abedi, A., Hansani Madushika Abeywickrama, Alemwork Abie, Aboagye, R.G

Neither structure is automatically superior

The abnormal accumulation of progerin initiates alteration of nuclear morphology (manifested as an accelerated aging phenotype) 5

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As a result of this process there is an overabundance of oxidants compared to anti-oxidants