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Cardiovascular adaptation represents another consideration for extended use

This typically resolves within the first two weeks

This recent preclinical study showed that the metabolism of racemic ketamine to (2 R ,6 R )-HNK is necessary for the antidepressant effects of ketamine, and that this metabolite itself shows antidepressant-like effects in mice that seem to be independent of the NMDAR

Case reports further indicate that mitochondrial impairment by sertraline may cause muscle weakness and multiple acyl-CoA dehydrogenase deficiencies in treated patients

J.LeustekT.GlassA

Neutral to mildly alkaline conditions favor the intact complex