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Carnitine and acylcarnitine can also be used as metabolic messengers to participate in the communication between tissues and coordinate energy metabolism between tissues

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

Gastroenterology 111:871885 Cross RK, Wilson KT (2003) Nitric oxide in inflammatory bowel disease

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Supporting these pathways is particularly relevant for individuals recovering from severe viral infections, where the accumulation of cellular waste can perpetuate systemic inflammation and fatigue