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China Patent CN102586369 (B) Liang G, Du G, Chen J (2008a) A novel strategy of enhanced glutathione production in high cell density cultivation of Candida utilis Cysteine addition combined with dissolved oxygen controlling

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A clinical trial encompassing 2185 patients with stage 4 CKD and diabetes demonstrated that, compared with placebo, CDDO-methyl ester treatment yielded a significant improvement in the estimated glomerular filtration rate (eGFR) and a reduction in the incidence of kidney-related adverse events [179, 180]