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Broad gene expression studies show it acts as an "on/off switch" that inhibits inflammation while promoting cell-extracellular matrix interactions

Activation of both GIP and GLP-1 receptors by retatrutide probably contributed to the observed changes in circulating triglycerides, as treatment with the dual GIP/GLP-1 receptor agonist tirzepatide significantly reduced triglyceride levels by up to 29% at 52 weeks in a clinical trial in people with T2D and MASLD 8

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Once blood sugar levels decrease closer to normal values, the pancreas response to produce insulin is reduced

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