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Furthermore, peripheral nerve injury leads to neuropathic pain, and the spared nerve injury (SNI) model in mice induces persistent heat hyperalgesia 44
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The prefrontal cortex is highly sensitive to DA and even minor fluctuations can impair prefrontal cortex-dependent functions, making it particularly relevant in PTSD, as it plays a central role in suppressing fear responses, regulating stress reactivity, and enabling emotional control (Cools and D'Esposito, 2011)
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