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Duration of Use Phentermine is approved for short-term treatment, typically capped at 12 weeks, because tolerance may develop and the risk of dependence increases with prolonged use

Alternative medications or close monitoring might be necessary

For those who have already had cholecystectomy, the risk of gallbladder stones is eliminated, though bile duct stones (choledocholithiasis) can still occur, albeit less commonly

The efficacy and safety of combinations of SGLT2 inhibitors and GLP-1 receptor agonists in the treatment of type 2 diabetes or obese adults: a systematic review and meta-analysis

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Beta-cell secretion studies use isolated pancreatic islets from rodent or human donors, exposing them to sema at defined concentrations during glucose-stimulated insulin secretion (GSIS) assays