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In clinical trials conducted using the once to weekly subcutaneous semaglutide injection, combined with lifestyle interventions, participants treated with semaglutide demonstrated greater reductions in body weight at least 15 percent of their baseline body weight compared to those who received a placebo
Torres-Daz, A
Liraglutide has been available longer (since 2015), but semaglutide also has extensive safety data from its use in diabetes
But even as far back as 1995, as Knudsens team was screening some of their early designs in mice, they saw that in addition to increasing insulin secretion, GLP-1 agonists made them eat less
10.1038/s41419-023-06177-1 29 SuL.DongY.WangY.GuanB.LuY
That may help adults and children aged 12 years and older with obesity, or some adults with overweight who also have weight-related medical problems, to help them lose excess body weight and keep the weight off
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