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These interactions can make semaglutide less effective or make its side effects worse

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We recommend: Cleaning Up Your Diet: A few days prior, reduce your intake of fried, greasy, or highly spicy foods, as these are the most common triggers for nausea once the medication is active

(2024, September) Retatrutide is a novel triple-agonist targeting GLP-1, GIP, and glucagon receptors, showing in phase 2 trials that it can deliver remarkably large weight losses (up to ~24% over 48 weeks in people with obesity) along with strong improvements in HbA1c, lipid profiles, liver fat (in NAFLD), insulin sensitivity, and other cardiometabolic markers

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