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Following a similar approach, it was demonstrated that a decreased level of SFN results in neuroinflammation and oxidative stress, as indicated by lower concentrations of malondialdehyde, TNF- , and IL-1, respectively (85)
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Dot plots show the CHIP analysis results on CREM binding to the promoter of Gpx4 from neutrophils (n = 6) with indicated treatment: IFN- (10^5 U ml -1 ), anti-IFNAR (10 g ml -1 ), SLE IgG (2.4 g L -1 ) or SLE sera with IgG depletion
However, starting later (2-4 weeks post-fracture) still beneficial for remodeling phase
