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Furthermore, GLP-1 RAs mitigate hemodynamic burden associated with individuals with obesity and hypertension, contributing to their overall cardiovascular benefit 32

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Mean body weight reduction reached approximately 24 percent at the highest dose tier a magnitude that, investigators have noted, exceeds the Phase 2 outcomes reported for dual GLP-1/GIP agonists at comparable trial durations (PMID 37366315)

Caution is also needed in those with severe gastrointestinal disease, a history of pancreatitis, or significant psychiatric comorbidity requiring specialist input