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In the Lira Pump study, they decreased basal insulin by 10%, but increased bolus by 15% ( Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes

It specifically engineers them to avoid the phenomenon of long-term reliance

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However, ideally in clinical practice, we hope to achieve at least 10-15% [bodyweight loss], which can lead to more meaningful metabolic health, says Glickman, a triple board certified family medicine, lifestyle medicine, and obesity medicine physician and the founder of Revolution Medicine

In addition, reactions (rash or itching) at the injection site, insomnia, dizziness, and fatigue may occur

The saliva of the Gila monster creates a substance that looks very similar to the GLP-1 our body naturally makes, explains Andrea Traina, PharmD, obesity medical director for Novo Nordisk