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It is believed to influence cellular signaling pathways, including the activation of mechanisms critical for tissue repair and regeneration

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22,53 In the LEADER trial, which enrolled 9,340 patients with T2D at high cardiovascular risk, liraglutide demonstrated modest reduction in systolic BP (mean difference: 1.2 mm Hg

11 Further evidence for increased oxidative stress has been demonstrated in the rodent PPA model, including increased brain protein carbonylation and lipid peroxidation, altered phospholipid profiles and increased activated microglia

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