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The BP of the plant species called Echium vulgare possesses high pyrrolizidine alkaloid contents in most European countries (206), while the toxic elements include aluminum, lead, strontium, cadmium, arsenic, chromium, nickel, and mercury, which can cause neurotoxicity and other abnormalities (207)

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Experimental studies indicate that supraphysiological testosterone exposure increases reactive oxygen species generation within cardiomyocytes while reducing the activity of endogenous antioxidant enzymes, including superoxide dismutase and glutathione peroxidase (72)

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