Optimization of triazole-based TGR5 agonists towards orally available agents
In a Phase III trial of 886 patients, Keytruda, a PD-1 inhibitor, plus Padcev, an antibody-drug conjugate, reduced the risk of death by 53% over platinum-based chemotherapy
When 2-CTC (2-trityl chloride resin) is used as a reaction carrier, a weak acid is used, which very easily causes the linker to fall off and the polypeptide fragment to be cleaved, leading to a greatly reduced final yield, an increase in production cost and a decrease in economic efficiency
This consensus provides the ultimate, evidence-based framework for the modern treatment strategies discussed in this article
Seine physiologische Konzentration nimmt mit dem Alter ab (von ~200 ng/ml mit 20 Jahren auf ~80 ng/ml mit 60 Jahren)
Maintenance dosing of drugs like retatrutide is turning out to be significant