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The following p21 siRNA sequences were used: sense (5-GTTGACGATGCCTTCTATA-3)

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The coupling reaction was initiated by incubation at 25 C for 1 h and was followed by the addition of Apyrase (New England BioLab) to catalyze the hydrolysis of GDP overnight at 4 C

Data availability The authors declare that all data supporting the findings of this study are provided in the Manuscript and its Supplementary Information/Source Data files

Fluorescence detection: Derivatization with fluorescent tags such as monobromobimane (mBBr) or o-phthalaldehyde (OPA) enables highly sensitive fluorescence detection