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Due to the complexity of NASH, no current treatment is approved for it (126) and most therapies remain to be traditional and focus on lifestyle intervention, which is difficult to maintain (127)
Each dose level is maintained for 4 weeks before increasing
Semaglutide and Tirzepatide are both GLP-1 receptor agonists, with Tirzepatide having additional action on and a higher affinity for glucose-dependent insulinotropic polypeptide (GIP) receptors
Some providers also use microdosing approaches with tirzepatide or adjust timing to address plateaus
Those with type 1 diabetes should not be prescribed semaglutide injections, along with anyone who is at a higher risk or has a family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 due to any further increase of risk that could be caused by the injections
Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies
